Investigación

Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Godoy LC, Muñoz-Pinedo C, Castro L, Cardaci S, Schonhoff CM, King M, Tórtora V, Marín M, Miao Q, Jiang JF, Kapralov A, Jemmerson R, Silkstone GG, Patel JN, Evans JE, Wilson…
Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Peluffo G, Calcerrada P, Piacenza L, Pizzano N, Radi R. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1781-92. Epub 2009 Apr 10.
Sulfenic acid--a key intermediate in albumin thiol oxidation. Turell L, Botti H, Carballal S, Radi R, Alvarez B. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15;877(28):3384-92. Epub 2009 Mar 28. Review.
pH-sensitive binding of cytochrome c to the inner mitochondrial membrane. Implications for the participation of the protein in cell respiration and apoptosis. Kawai C, Pessoto FS, Rodrigues T, Mugnol KC, Tórtora V, Castro L, Milícchio VA, Tersariol IL, Di Mascio P, Radi R, Carmona-Ribeiro AM, Nantes IL. Biochemistry. 2009 Sep…
Inactivation of cystathionine beta-synthase with peroxynitrite. Celano L, Gil M, Carballal S, Durán R, Denicola A, Banerjee R, Alvarez B. Arch Biochem Biophys. 2009 Nov;491(1-2):96-105. Epub 2009 Sep 3.
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide. Redondo-Horcajo M, Romero N, Martínez-Acedo P, Martínez-Ruiz A, Quijano C, Lourenço CF, Movilla N, Enríquez JA, Rodríguez-Pascual F, Rial E, Radi R, Vázquez J, Lamas S. Cardiovasc Res. 2010 Mar 3. [Epub ahead of print]
Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity. López GV, Gómez LE, Campillo N, Páez JA, Giles K, Atkinson J, González M, Rubbo H, Cerecetto H. Bioorg Med Chem. 2009 Dec 15;17(24):8143-8. Epub 2009 Oct 29
Lipid Peroxyl Radicals Mediate Tyrosine Dimerization and Nitration in Membranes. Bartesaghi S, Wenzel J, Trujillo M, Lo?pez M, Joseph J, Kalyanaraman B, Radi R. Chem Res Toxicol. 2010 Feb 19. [Epub ahead of print]
Thiol-sensitive mutant forms of human SOD2, L60F, and I58T: the role of Cys140. Hernandez-Saavedra D, Quijano C, Demicheli V, Souza JM, Radi R, McCord JM. Free Radic Biol Med. 2010 May 1;48(9):1202-10. Epub 2010 Feb 6.
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Hugo M, Turell L, Manta B, Botti H, Monteiro G, Netto LE, Alvarez B, Radi R, Trujillo M. Biochemistry. 2009 Oct 13;48(40):9416-26.
Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved? Boiani M, Piacenza L, Hernández P, Boiani L, Cerecetto H, González M, Denicola A. Biochem Pharmacol. 2010 Jun 15;79(12):1736-45. Epub 2010 Feb 21.
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