International Symposium and Workshop: “Neuroinflammation in Health and Disease”

April 3rd-10th 2019

Institut Pasteur de Montevideo, Facultad de Medicina e IIBCE.

Organizers: L. Barbeito, P. Cassina, N. Lago, S. Olivera, H. Peluffo



April 3rd

 13:00-14:00: Accreditation

Introductory lectures:

14:00-14:30: Metabolic interaction between neurons and glial cells. (Patricia Cassina, Facultad de Medicina UdelaR, Uruguay)

14:30-15:00: Microglia and myeloid cells in the CNS: new methodologies to identify different phenotypes (Hugo Peluffo, Facultad de Medicina, IPMont, Uruguay)

15:30-16:00: Neuroinflammation in acute CNS and PNS trauma (Natalia Lago, IPMont, Uruguay)


-----------------------------------16:00-16:30 Coffee Break-----------------------------------


16:30-17:00: Glial cells and aberrant glial phenotypes in neurodegeneration (Luis Barbeito, IPMont, Uruguay)

17:00-17:30: Oligodendrocytes as vulnerable targets of neuroinflammation. (Silvia Olivera, IIBCE, Uruguay)


Thursday April 4th

Session 1: Mediators of neuroinflammation I

Moderator: Hugo Peluffo

9:00-9:40 Alterations in CD300f immunoreceptor are associated with major depressive disorder in mice and humans(Hugo Peluffo, Fmed, IPMont, Uruguay)

9:40-10:20 Aging and neuroinflammation in neurodegeneratives diseases (Rommy von Bernhardi, PUCC, Chile)


-----------------------------------10:20-11:00 Coffee Break-----------------------------------


11:00-11:40 Can we boost CNS repair by stimulating anti- inflammatory macrophages? (Rubèn López-Vales, UAB, España)

11:40-12:20 The role of the immune system in the generation of neuropathic pain.

(Margarita Calvo, PUCC, Chile).


-----------------------------------12:20-14:00 Almuerzo---------------------------------------


Session 2: Mediators of neuroinflammation II

Moderator: Natalia Lago

14:00-14:40 Finding Parkinson´s disease related genes studying neuroinflammation (Fernando Pitossi, Instituto Leloir, Argentina)

14:40-15:20 Glial cells as main actors in an experimental model of Parkinson disease (Silvia Olivera, IIIBCE, Uruguay).  

15:20-15:50 Pericyte response to glutaric acid and astrocyte-conditioned media (Eugenia Isasi, IIBCE-FMed, Uruguay)


 ---------------------15:50-16:30 Coffe break and poster sesión ----------------------


16:30-17:10 The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (Felipe CourtUniversidad Mayor, Chile) 

17:10-17:40 Potential role of alpha-Synuclein in neuroinflammation (José Souza, FMed, Uruguay) 


Friday April 5th

Session 3 Neuroinflammation in ALS

Moderator: Luis Barbeito

 9:00-9:40: Contrasting role of the immune response in the central and peripheral nervous system in the ALS models. (Caterina Bendotti, IRFMN, Italy)

9:40-10:20 Glial cells and the emerging concept of neuroprogression in ALS. Luis Barbeito IPMont, Uruguay


---------------------10:20-10:50 Coffe break ------------------------


10:50-11:30 Interleukin 37: a novel cytokine that confers protection against ALS. (Rubèn López-Vales, UAB, España)

11:30-12:10 Novel lipidomic markers and therapeutic potential of nitro-fatty acids in ALS. (Homero Rubbo, Fmed, Uruguay).

12:10-12:40 Significance of peripheral nervous system inflammation in ALS paralysis progression: therapeutic implications (Emiliano Trías, IPMont, Uruguay)


-----------------------------------12:40-14:00 Almuerzo---------------------------------------


Session 4 Astrocytes in neuroinflammation

Moderator: Patricia Cassina

14:00-14:40 Astrocytes and the TGF-?1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword. (Flavia Gomes, UFRJ, Brazil).

14:40-15:20 Astrocytes as active players in brain neuroinflammation: Lessons from ischemia, TBI and epilepsy (Javier Ramos, UBA Argentina)

15:20-15:50 Metabolic modulation of glial cells in ALS models (Laura Martínez-Palma, Fmed, Uruguay)


----------------------15:50-16:30 Coffe break-and Poster session----------------------


16:30-17:00 Astrocyte neuron communication by extracellular vesicles (Soledad Marton, FMed, Uruguay)

17:00-17:40 Pro-regenerative effect of glial exosomes and its modulation by transcriptional programs (Felipe Court, Universidad Mayor, Chile) 

17:40-18:30 Concluding remarks


Saturday April 6th

 9:00-10:30: 10 min Students presentations


---------------------10:30-10:50 Coffe break ------------------------


10:50-11:50 10 min Students presentations

11:50-12:15 Hands on groups distribution and seminar instructions


 Monday 8th-Tuesday 9th

 Hands on 9:00 – 16:00

5 groups of 3-4 students

1)    Evaluation of metalloprotease activity in the ALS experimental model SOD1G93A rats. (Silvia Olivera/Marta Marco)

2)    Identification of Inflammatory mediators by qPCR in ALS models (Soledad Marton).

3)    Analysis of glial reactivity in pain and ALS models (Laura Martinez/ Valentina Lagos/ Ernesto Miquel)

4)    Identification of different cell populations after Spinal Cord Injury by flow cytometry (Natalia Lago)

5)    Analysis of peripheral nervous system pathology in a murine model of motor neuron disease. (Sofía Ibarburu)


Wednesday 10th

 9:00-10:30 Hands on results and manuscripts presentation by the different student´s groups

 Round table - Closing

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